Oxford Outcomes Oxford Outcomes Oxford Outcomes Oxford Outcomes

Risk-benefit modeling

Risk-benefit modeling informs the increasing focus on the safety and efficacy of new therapies from a population perspective, it jointly evaluates the risks and benefits of competing therapies using the quality-adjusted life year as a common metric. This analysis allows the explicit incorporation of patient or societal preferences for the targeted health states, and is a flexible strategy that can employ trial or real-world safety and efficacy/effectiveness data. A risk-benefit modeling approach is particularly valuable for therapies with potentially contentious or poorly understood safety profiles.

 

Regulators have taken a special interest in risk benefit studies because of their contribution towards the lifecycle management approach to drug licensure that many countries are moving towards. Our Epidemiology team has a wealth of experience in conducting risk-benefit modeling and we are able to use this expertise to provide a well informed and thorough service either as a stand alone product or in conjunction with our other services.